The Action Subtargets option has been added to the configuration menu, under Target Settings. Toggling off disables the selection of alternate targets for actions executed directly from the action bar; actions will instead be performed on the current target.
* Setting can also be toggled via a text command.

/subtarget(/st) [subcommand]

The Action Reselect Cancel option has been added to the configuration menu, under System.
Enable canceling of actions by selecting them again from the action bar while they are being cast or channeled.
* Can also be performed via the text command /actioncancel, (/acan).

/actioncancel [subcommand] 　
The setting will be defaulted to off for all characters. The setting must be enabled if you wish to be able to cancel actions via the action bar as before.

Players can now choose from two keyboard layouts: Type A, the default FFXIV layout, or Type B, the standard MMORPG layout.
Check out this forum post for more information.

More key mapping options are now available under Keyboard in the configuration menu.

The Face Target command, found under Keyboard in the configuration menu, has been changed.
The action is no longer accompanied by a motion; characters will now instantly face the target, and those in motion will come to an immediate halt.
* Can also be performed via the text command /facetarget, (/ft)